Wise Jr., the first African-American doctor admitted to practice at Prince George's Hospital and a Tuskegee Airman.

Wise Jr. High School offers four notable Career and Technical Educational programs (CTE) in Business and Finance, Health and Bioscience, Information Technology, and Child Growth and Development.

[10] These CTE programs helps students gain the skills, technical knowledge, academic foundation, and real-world experience they need to prepare for high-skilled, high-demand, high-wage jobs.

In 2021, a family sued Prince George's County Schools over their handling of an alleged campus sexual assault between a developmentally disabled 14-year-old girl and six boys.

[11] In January 2023, a Wise High teacher 'inadvertently' sent sexually explicit photos to students, and action was taken by the administration to retract the message.

[citation needed] The gymnasium has a capacity of 5,000 seats, making it the largest of any PGCPS school; the gym's second floor has a running track.

In 2012 The Washington Post reported that area community members complained that the parking lot was too small for use for major events; there was a desire to have the Wise gymnasium used for such events so the county government would not have to rent venues of similar sizes, and therefore spend less money.