Comedians Maria Bamford, Kathy Griffin, Andy Kindler and Paul F. Tompkins appeared in person as celebrity "clients"; Jon Benjamin and Laura Silverman reprised their respective roles from the animated series.

In January 2008, live performances were presented over two nights as part of SF Sketchfest in San Francisco, California.

On the first night, Jonathan Katz's guest list included Maria Bamford, Brian Posehn and Bob Odenkirk.

This performance, commemorating the 20th anniversary of the program, featured Katz with Jon Benjamin and Tom Snyder again portraying his son and therapist, respectively.

Staged therapy sessions included Andy Kindler, Emo Philips, Maria Bamford, Dom Irrera, Dana Gould, and Eddie Pepitone.

The patients who booked "appointments" that night included Janeane Garofalo, Andy Kindler, Maria Bamford, The Sklar Brothers, and Chelsea Peretti.

Katz did a short stand-up comedy set Guest "patients" included Kevin Pollak, Natasha Leggero, Tom Papa, Moshe Kasher and Scott Aukerman.

He is a laid-back, well-intentioned man who enjoys playing the guitar and spending time at the bar with his friend Stanley and bartender Julie.

[11] Those that feature comics generally consist of onstage material contributed by the guest, while Dr. Katz offers insights or simply lets them talk.

[citation needed] Interspersed between therapy sessions are scenes involving Dr. Katz's daily life, which includes his aimless, childish 24-year-old son Ben (Jon Benjamin), his uninterested and unhelpful secretary, Laura (Laura Silverman), and his two friends: Stanley (Will LeBow) and bartender Julie, voiced by one of the show's producers, Julianne Bond (credited as Julianne Shapiro).

The plots include events like Ben attempting to become a radio personality, believing he has ESP, or suffering from a moral conundrum after receiving a chain letter.

This style, as well as the animation technique Squigglevision, would reappear in Home Movies, another series on which many members of the Dr. Katz cast and crew worked.