The game's soundtrack was composed by Seiichi Tokunaga, featuring arrangements of classic Dr. Mario tunes and new compositions.

[3] The game was re-released on the Nintendo Switch Online + Expansion Pack in October 2021, marking its first release in PAL territories.

The playing field is represented on-screen as a medicine bottle populated with viruses of three colors: red, blue, and yellow.

The main objective of the game to clear the playing field of all the viruses using two-colored medical capsules dropped into the bottle.

The player receives a game over if the playing field fills up with capsules such that they obstruct the bottle's narrow neck.