Dreiskau-Muckern is an Ortsteil (division) of the municipality Großpösna in the Landkreis Leipzig in Saxony, Germany.

It was formed in 1957 from the former municipalities Dreiskau and Muckern, and became part of Großpösna in 1997.

The Catholic parish Dreiskau was part of the Diocese of Merseburg.

Muckern was first mentioned in 1433, as Mockeryn in a document kept in the Domarchiv Merseburg.

It belonged to the Rittergut of the noble family Zehmen [de].