It encompasses an area of approximately 258 square miles (670 km2) with a population of 32,241 (as of 2000).

In Jefferson County it covers the Boroughs of Falls Creek, Reynoldsville and Sykesville and Winslow Township.

High school students may choose to attend Jefferson County Dubois Area Vocational-Technical School for training in the construction and mechanical trades, the culinary arts and allied health careers.

The Riverview Intermediate Unit IU6 provides the district with a wide variety of services like specialized education for disabled students and hearing, speech and visual disability services and professional development for staff and faculty.

Dubois Area School District offers a wide variety of clubs, activities and an extensive sports program.