Du Quoin (/duːˈkɔɪn/ doo-KOYN) is a city in Perry County, Illinois, United States.

There it turned to the southeast to cross the Big Muddy River and head for Lusk's Ferry.

Du Quoin had its start at its present location in 1853 when the railroad was extended to that point.

[4] The city was named after Chief Jean Baptiste Ducoigne of the Kaskaskia, an Illiniwek people, who were defeated by the Shawnee near here in 1802.

[5] The city of Du Quoin is located in the southeastern portion of Perry County, Illinois.

[9] Amtrak, the national passenger rail system, provides service to Du Quoin.

Amtrak Train 391, the southbound Saluki, is scheduled to depart Du Quoin at 1:17 pm daily with service to Carbondale.

Amtrak Train 390, the northbound Saluki, is scheduled to depart Du Quoin at 7:51 am daily with service to Centralia, Effingham, Mattoon, Champaign-Urbana, Rantoul, Gilman, Kankakee, Homewood, and Chicago.

(https://www.duquoinschools.org/) The DuQuoin State Fair is held in late August and early September since 1923.

Du Quoin is known for the large amount of Canada Geese that migrate for winter and to nest in Spring.