Duke Street was originally a Poor Law hospital, commissioned by the Glasgow Parish Council.

The facility, which was designed by Alfred Hessell Tiltman in the French Renaissance style,[1] was opened as the Eastern District Hospital in September 1904, on the same day as the Western District Hospital at Oakbank in Maryhill and Stobhill Hospital in Springburn.

[2][3] A new maternity unit was completed in the 1940s and it joined the National Health Service in 1948.

[2] After services had transferred to Parkhead Hospital,[4] it closed in 1992.

[2] The main building, which is Category B listed, was converted to residential use in the 2000s, having lain empty for some years.