Duke of Abrantes (Spanish: Duque de Abrantes) is a hereditary title in the Peerage of Spain, accompanied by the dignity of Grandee and granted in 1642 by Philip IV to Alfonso de Láncaster, son of the 3rd Duke of Aveiro and a great-grandchild of John II of Portugal.

This ducal family formerly owned the Palacio de los Toledo-Moctezuma at Cáceres in Spain.

The Habsburgs were deposed from the Portuguese throne in 1640, two years before this dukedom was created.

The title was never recognised in Portugal, but it remains extant in Spain.

The present Duke of Abrantes, who is also a Grandee of Spain, is Don José Manuel de Zuleta y Alejandro, who is the Private Secretary to Queen Letizia.