It is situated 30 kilometres (19 mi) from the town of Třebíč, near the Dalešice Reservoir, where the plant sources its water supply.

In 1970 Czechoslovakia and the Soviet Union ratified a contract for construction of two nuclear power plants.

In total an extra 240 MWe of capacity has been or will be added before 2013 in a comprehensive program of improvements including steam plant replacement, addition of instrumentation and fuel changes.

In 2023, ČEZ planned to invest more than CZK2.3 billion ($105 million) mainly to ensure "safe and reliable operation until at least 2047" with a lifetime of at least 60 years.

A pipeline over 40 kilometres in length could be installed after regional officials have considered ČEZ's environmental impact statement for the project, submitted in July 2010.

[5] In April 2021, it was announced that Russia's Rosatom would be excluded as well,[6] after it has been alleged that two Russian agents were perpetrators of the 2014 Vrbětice ammunition warehouses explosions.

[11] The Dukovany reactor complex appears in the video game Tom Clancy's EndWar as a potential battlefield.