Fifty students in each grade take Honors, Advanced Placement, and Dual Enrollment classes on the DHS campus.

The program is supported by Duke Energy and is great for students interested in careers in engineering and power generation.

The following vocational programs are also offered: Health Occupations, Administrative Office Tech, Culinary Arts, Agriculture, Building Construction, Early Childhood Education, Digital Video Productions, Power Generation, Game Simulations, Web Design, and Teacher Assisting.

The school used to have an Air Force Junior Reserve Officer Training Corps (AFJROTC) program, which was shut down in 2023.

Current NFL players Terrence Brooks and Lerentee McCray are Dunnellon High School graduates.