They have produced films such as The Puffy Chair (2005), Safety Not Guaranteed (2012), The One I Love (2014) and The Skeleton Twins (2014), and the HBO comedy-drama television series Togetherness (2015–2016) and Room 104 (2017-2020).

The company originally produced low-budget mumblecore films,[1] but has since expanded to studio projects.

[4] Under the TV production arm Duplass Brothers Television, they signed a two-year overall deal with HBO in June 2015.

[5] In August 2016, Duplass Brothers announced another television project, Room 104, to air on HBO in 2017,[6] which was quickly renewed for a second season.

[7] In 2018, it was announced the company had entered into a new four-picture deal with Netflix, which gave the streaming giant worldwide rights.