Duran Esmoris Residencia is a building in Mayagüez, Puerto Rico, situated on less than an acre of land on Mendez Vigo Street.

Designed by architect, Luis Fernando Nieva, the building is generally rectangular in shape.

Built in 1921, the people who lived in the residence were prominent members of the municipality of Mayagüez.

The Duran Esmoris residence features tall ceilings, mosaic and stained class making it one of the last remaining structures with good representation of what the character of Mendez Vigo Street was in the early 20th century.

This article about a property in Puerto Rico on the National Register of Historic Places is a stub.