Durhamville is a rural unincorporated community in Lauderdale County, Tennessee, United States.

[3] Blues guitarist Sleepy John Estes is buried at Elam Baptist Church Cemetery in Durhamville.

During the American Civil War, a detachment of the 52nd Indiana Volunteer Infantry engaged Confederate troops at Durhamville in 1862.

Sleepy John Estes was a U.S. blues guitarist, songwriter and vocalist, born in Ripley, Lauderdale County.

The settlement is situated on the southeastern edge of the New Madrid Seismic Zone, an area with a high earthquake risk.