District of Columbus, Kentucky, XIII Corps, Department of the Tennessee, to January 1863.
3rd Brigade, 2nd Division (detachment), Army of the Tennessee, Department of the Cumberland, to February 1865.
Withdrew April 18, 1862: Moved to Pittsburg Landing, TN in the aftermath of the Battle of Shiloh April 29, 1862 - May 30, 1862: Advance on and sieged of the town of Corinth, TN as General Henry Halleck pursued confederate General P. G. T. Beauregard in retreat from Shilo.
September 19–25, 1863: Expedition to Jackson, MS (as a detachment) September 28, 1863 - October 5, 1863: Expedition to Covington, Durhamsville, and Fort Randolph November 21, 1863 – November 22, 1863: Scout from Fort Pillow January 18, 1864: Ordered to Vicksburg, Mississippi February 3, 1864 - March 2, 1864: Meridian Campaign February 5, 1864: Clinton February 14–15, 1864: Meridian, MS March 1864 - April 1864: Veterans absent on furlough March 4, 1864: Left Vicksburg, MS March 17, 1864: Return to Rushville, IN April 23, 1864: Left for the field April 26, 1864: Reached Columbus, Kentucky Moved to Morganza, Louisiana Moved to Vicksburg, MS Non-veterans temporarily attached to the 89th Indiana Infantry.
March 10, 1864 - May 22, 1864: Red River Campaign March 14, 1864: Fort DeRussy March 21, 1864: Bayou Rapides April 9, 1864: Battle of Pleasant Hill April 23, 1864: Cane River Crossing April 26, 1864 - May 13, 1864: At Alexandria, LA May 3, 1864: Moore's Plantation May 6, 1864: Bayou LeMourie May 13–20, 1864: Retreat to Morganza, MS May 16, 1864: Mansura May 18, 1864: Yellow Bayou May 20-June 10: Moved to Vicksburg, Mississippi then to Memphis, Tennessee, June 6–7, 1864: Lake Chicot, Arkansas June 23, 1864: Colliersville, Tennessee June 23, 1864: Near Lafayetteville July 5–21, 1864: Smith's Expedition to Tupelo, MS July 11–12, 1864: About Pontotoc July 14–15, 1864: Harrisburg, Tupelo, MS July 15, 1864: Old Town (or Tishomingo) Creek August 1, 1864 – August 30, 1864: Smith's Expedition to Oxford, Mississippi September 26, 1864 -November 19, 1864: March through Missouri in pursuit of Price November 26-December 1, 1864: Moved to Nashville, Tennessee December 15–16, 1864: Victory at the Battle of Nashville December 17–23, 1864: Pursuit of Hood to the Tennessee River December 24, 1864 - February 1865: Duty at Clifton, Tennessee, and Eastport, Mississippi February 6–17: Moved to New Orleans, LA March 17-April 12, 1865: Campaign against Mobile and its defenses March 26, 1865 - April 8, 1865: Siege of Spanish Fort and Fort Blakely April 9, 1865: Assault and capture of Fort Blakely April 9 April 12, 1865: Occupation of Mobile, Alabama April 13–25, 1865: Moved to Montgomery, Alabama April 25, 1865 - July 14, 1865: Duty at Montgomery, AL May 25, 1865: Troops from the disbanded 50th Indiana Infantry Regiment joined the regiment July 15, 1865 - August 28, 1865: At Tuskegee, Alabama September 10, 1865: Regiment mustered out of service and all troops discharged September 21, 1865: The surviving veterans of the 50th Infantry returned home to Seymour, Indiana The regiment lost a total of 205 men during service; 2 officers and 26 enlisted men killed or mortally wounded, 2 officers and 175 enlisted men died of disease.