It divides the city in half as it crosses it between the Ojibway Parkway in the west and Banwell Road in the east, a distance of 15.4 kilometres (9.6 mi).

This situation is being rectified from 2011 onward, as the expressway's western terminus is located at the port of entry for the Gordie Howe International Bridge scheduled for completion in 2025,[5] with slip ramps to access the bridge-bound portion of Highway 401.

Slip ramps provide access between the two parallel freeways before the parkway diverges and travels under the eastbound carriageway of the E. C. Row to the west of Huron Church Road.

After interchanges with Dominion Boulevard and Dougall Avenue, the route crosses the Canadian National (CN) Caso subdivision railway lines and briefly passes through an industrial area.

The commercial zoning eventually transitions to agricultural fields, and the E. C. Row Expressway curves northeast and intersects Banwell Road at-grade.

[6] One of the primary issues identified by the study was "a limited and inadequate street network in the east-west direction generally resulting from several railway barriers".

However, with the release of WATS and the subsequent amalgamation in 1966 in which Windsor annexed portions of the surrounding townships, plans for an expressway along the corridor were first conceived.

[6] The original plans for the expressway dating back to 1969 were for it to travel from current County Road 22, heading west along the southern edge of Belle River and Tecumseh, meeting up with the current two-lane freeway alignment (Pike Creek Bypass) just east of Puce, as well as having the west end continue south through Lasalle to north of Amherstburg.

By early 1980, the existing construction contracts were completed, and work began to connect the expressway between Huron Church Road and Dougall Avenue.

[18] The province later stepped in to provide a share of the funding in March 1987,[19] and work began with contracts being awarded for construction on August 26 and September 16 of that year for interchanges at Dominion Boulevard and Huron Church Road, respectively.

[20] The City of Windsor also negotiated with the province for funding of an interchange at Matchette Road in late April of that year,[21] which was approved by September 1.

[23] Work began in October 1989 to twin the existing two-laned route between the Ojibway Parkway and Huron Church Road by building a second parallel roadway to serve as the eastbound lanes.

[2] The project was completed on November 21, 2015 and allows E. C. Row traffic to connect with the bridge-bound portion of Highway 401 via slip ramps located east of Machete Road.