[2] Patent assigned to US Army for EA-4056 among other similar nerve agents was filed in December 7, 1967.

In general their penetration through the blood-brain barrier is difficult due to quaternary nitrogens in these molecules.

[1] For VX, the median lethal dose (LD50) for 70 kg men via exposure to the skin is estimated to be 10 mg, and the lethal concentration time (LCt50), measuring the concentration of the vapor per length of time exposed, is estimated to be 30–50 mg·min/m3.

For a different product other secondary amines than dimethylamine can be used; such as those containing methyl, ethyl, propyl, isopropyl, butyl and benzyl groups.

1 mol α,ω-dihaloalkane (e.g. 1,9-dibromononane in this case) in acetonitrile is heated on a steam bath for 6 hours.

[3][6] Other stable salts of EA-4056 than bromide can be made such as sulfate, nitrate, hydrogen, oxalate and perchlorate.