ESPN MLS GameNight is a video game of the sports genre released in 2000 by Konami and Saffire.

The game is considered to be an enhanced remake of ISS Pro Evolution, also published by Konami.

The sequel, ESPN MLS ExtraTime 2002, was released for PlayStation 2 in 2001, and for GameCube and Xbox in 2002.

The game also featured the option of choosing either English commentary (provided by Bob Ley) or Spanish commentary (provided by Luis Omar Tapia).

In Season Mode, the player participates in a full 32-game Major League Soccer season where they are tasked with having to deal with realistic injuries, unpredictable weather conditions, and mid-season trades.