One of the main new features of ISS Pro Evolution is a new game mode named the Master League.

The idea of the Master League, beside winning the whole competition, is to complete a squad with real players on terms of transfers.

Upon completion of the Master League, due to the lack of different divisions, clubs are not promoted or relegated, regardless of their finishing position.

The Master League game mode is present in every subsequent version in the ISS and PES series.

In successive versions of the series, throughout many modifications and improvements, the later versions of the Master League differ a lot from the original Master League used in ISS Pro Evolution, since the newer PES games are an emulation of a whole season with promotions and relegations being added due to new divisions, rather than having only one division.