The family produced several medical doctors beginning with John Farrell Easmon, the medical doctor who coined the term Blackwater fever and wrote the first clinical diagnosis of the disease linking it to malaria and Albert Whiggs Easmon, who was a leading gynaecologist in Freetown, Sierra Leone.

Several members of the family were active in business, academia, politics, the arts including music, cultural dance, playwriting and literature, history, anthropology, cultural studies, and anti-colonial activism against racism.

The earliest known progenitor of the Easmon family was William Easmon, (d. 1831), an African American trader possibly from North Carolina, who was one of the original Nova Scotian Settler emigrés from Nova Scotia, Canada, who established Freetown, Sierra Leone on 11 March 1792.

Walter Richard Easmon was a merchant based in the Republic of Guinea who was married three times.

Members of the Easmon family were prominent in the medical field in the nineteenth and twentieth centuries.