The East Mikwam River is a tributary of the Mikwam River, flowing into the Cochrane District, in the north-east of Ontario, in Canada.

The west side of this slope is served by Ontario road 652.

The surface of the river is usually frozen from early November to mid-May, however, safe ice movement is generally from mid-November to the end of April.

The adjacent hydrographic slopes of the East Mikwam River are: The East Mikwam River originates from a mountain stream (elevation: 324 metres (1,063 ft)).

From its source, the East Mikwam River flows on 19.4 kilometres (12.1 mi) according to the following segments: The confluence of the East Mikwam River is located in Newman Township at 42.7 kilometres (26.5 mi) west of the Ontario - Quebec border; 25 kilometres (16 mi) south of the mouth of the Mikwam River; 42.0 kilometres (26.1 mi) west of the mouth of the Burntbush River; 89.6 kilometres (55.7 mi) south-east of a bay south of Kesagami Lake and 20.1 kilometres (12.5 mi) southeasterly of Ontario Highway 652.