East Stroudsburg is a borough in Monroe County, Pennsylvania, and part of the Pocono Mountains region of the state.

In 1737, present-day East Stroudsburg was settled by Daniel Brodhead, a judge from Marbletown, New York, who acquired a 1,000-acre lot of land on and around where Lehigh Valley Hospital–Pocono Hospital currently stands at 206 E. Brown Street in what then was Bucks County and now is Monroe County along the east bank of Brodhead Creek, then known as the Analomink River.

Moravian missionaries, residing in Bethlehem to the town's south, often traveled through Danbury Manor on the way to Dutchess County, New York and other northern locations.

On December 11, 1755, six months after Brodhead's death, Danbury Manor was attacked by approximately 200 Native Americans.

While each of the Brodhead children were able to save the lives, the Native American attackers destroyed Danbury Manor.

In 1856, the Delaware, Lackawanna and Western Railroad was built through present-day East Stroudsburg, which greatly increased the town's population and economic vibrancy.

Pocono Medical Center began as General Hospital, and was founded in East Stroudsburg on Courtland Street in 1915; it became Lehigh Valley Hospital-Pocono in 2017.

Stroudsburg-Pocono Airport is located near East Stroudsburg, in Smithfield Township, Monroe County, Pennsylvania.

Stroudsburg-Pocono Airport serves East Stroudsburg and Monroe County and is owned by Robert Strenz.

The airport offers activities such as the Sky's the Limit Skydiving Center and a golf driving range.

The Red route connects the central business district with adjacent Stroudsburg and Pocono Medical Center.

The Yellow Route serves the Northern and Eastern portions of the borough, connecting them with the Stroud Mall, and the Marshall's Creek, PA area.

Rail transportation plays an important part in the history of the borough and continues to have an impact today.

The Pennsylvania Northeast Regional Railroad Authority is a bi-county creation of both Lackawanna County and Monroe County to oversee the use of common rail freight lines in northeastern Pennsylvania, including one formerly owned by Conrail running from Scranton, through East Stroudsburg towards New Jersey, and the New York City market, called the Pocono Mainline.

The newspaper also covers parts of Pike, Lackawanna, Wayne and Carbon counties as well as areas of western New Jersey.

Students and Faculty of the university provide programing often, and the station rebroadcasts BBC World Service when live DJs are not available.

WXPJ at (91.9 FM) as broadcast from Hackettstown, New Jersey, from Centenary College – independent programing and music, NPR.

During the winter months, the plant hardiness zone is 6a, with an average annual extreme minimum air temperature of −5.4 °F (−21 °C).

Ice storms and large snowstorms depositing ≥ 12 inches (30 cm) of snow occur once every couple of years, particularly during nor’easters from December through February.