It was located on the Central Massachusetts Railroad mainline east of the Landham Road overpass.

East Sudbury station was created by the Boston and Maine Railroad (B&M) before December 19, 1887 on the Central Massachusetts Branch.

[3][1]: 143 Service on the Central Mass Branch was terminated on November 26, 1971 due to poor track conditions and low ridership.

In 2022, a buried transmission line project between Sudbury and Hudson began construction under the former Central Massachusetts Railroad ROW for which it provided service.

[4] This project subsidized the cost of building a section of the Mass Central Rail Trail—Wayside, which is expected to complete construction in 2025.