The plain is punctuated with volcanic formations, such as Chlmecké kopce or Tarbucka.
Important rivers are Bodrog and its tributaries Ondava, Laborec, Latorica, Uh, and Topľa.
A system of protective dikes and drainage canals has been built, because the Bodrog tributaries had often caused floods.
Cold sulphur and hydrogen acidulous waters are used at the Sobrance health resort.
Rare water and swamp flora and fauna is also preserved in the Tajba reserve.