He was the son of Stephen Mack who died in 1814 as First Judge of the Broome County Court.
Ebenezer Mack was a printer, and co-published the Owego Gazette from 1815 to 1816, and the Ithaca American Journal from 1817 to 1823.
He was a trustee of the Village of Ithaca in 1823, and was a member of the New York State Assembly (Tompkins Co.) in 1830.
In 1841, he published The Life of Gilbert Motier de La Fayette (Mack, Andrus & Woodruff, Ithaca NY; 371 pages; on-line copy).
He died of consumption, and was buried at the City Cemetery in Ithaca NY.