She campaigned for an efficient preventive medicine, especially as an answer to the rising incidence of tuberculosis within large groups of the industrial worker population (as stated in her 1907 medical sociology work, Influenţa industriilor asupra sănătăţii lucrătorilor).
Once there, after being received in the ranks of the Russian Communist Party, Ecaterina Arbore was integrated in the administrative structure of the Ukrainian SSR, as Commissar for Health.
She became Health Commisar for the newly created Moldavian ASSR, being one of the Romanian/Moldovan intellectuals who endorsed the terms of the Soviet policy towards the Romanian state.
This is the time when she was paid a visit by Romanian author Panait Istrati, during the latter's revelatory journey to the Soviet lands (as described in his The Confession of a Loser).
Istrati praised the work carried by Arbore in the Health Department of the Republic, and likened her the legendary architect Meşterul Manole's wife, who according to myth, was walled in the monastery by her husband, who believed this to be the only thing able to prevent the building from collapsing; this is a reflection on the terror that was mounting in the Soviet Union, as a direct consequence of the state not being able to live up to its promise.