Echigo-Shimoseki Station (越後下関駅, Echigo-Shimoseki-eki) is a railway station on the Yonesaka Line in the village of Sekikawa, Niigata Prefecture, Japan, operated by East Japan Railway Company (JR East).

Echigo-Shimoseki Station is served by the Yonesaka Line, and is located 79.7 kilometers from the terminus of the line at Yonezawa Station.

The station has two opposed ground-level side platforms connected to the station building by a footbridge.

Echigo-Shimoseki Station opened on 10 August 1931.

The station was absorbed into the JR East network upon the privatization of JNR on 1 April 1987.