Echinocereus subinermis is a species of flowering plant in the cactus family Cactaceae, native to north, northwestern, and central Mexico.

The plant may also have up to ten slender, light yellow to gray marginal spines that are 0.1 to 3 centimeters long, but these too can be absent.

[1] The flowers are funnel-shaped, fragrant, and bright yellow, appearing near the shoot tips.

The gray-green, obovate fruits are thorny, contain white pulp, and split lengthwise when ripe.

[2] Accepted subspecies:[3] Echinocereus subinermis is found growing on rocky slopes in the deciduous oak forest of the Mexican states of Sonora, Sinaloa, Chihuahua, and Durango, in the western Sierra Madre Occidental at elevations between 200 and 1300 meters.