The arena has 7,513 permanent seats around three sides of a central floor suitable for hosting indoor sports events.

[1] In September 2015, the opening of sister venue Exhibition Centre Liverpool resulted in a broader offer for standing concerts and international sporting events.

[3] Since opening, the arena has attracted more than 7 million visitors to over 3,800 events, as well as generating £1.6 billion in economic benefit for the Liverpool City Region.

[4] In November 2018, it was announced that the Echo Arena Liverpool would be renamed to its current title, as part of a sponsorship deal with M&S Bank.

[8] On the evening of 31 December 2017, a fire broke out in an adjacent multi-storey car park and as a consequence, the Liverpool International Horse Show, taking place at the arena, had to be cancelled.

[12] The arena has hosted various entertainment events, including the 2008 MTV Europe Music Awards, and concerts by artists such as Justin Bieber, Little Mix, Paul McCartney, Beyoncé, and others.

[13] On 7 October 2022, the BBC and the European Broadcasting Union (EBU) announced that the venue would host the Eurovision Song Contest 2023 on behalf of the previous year's winning country Ukraine, who was unable to meet the demands of hosting the event due to security concerns caused by the Russian invasion of Ukraine.

In November 2021, the arena was intended as the venue for the final of the 2021 Wheelchair Rugby League World Cup but was postponed by a year due to the COVID-19 pandemic.

The arena is situated opposite the portal of the now disused Wapping Tunnel, which runs from Edge Hill in the east of the city.