Eclipse Phase is a science fiction horror[2] role-playing game with transhumanist, post-apocalyptic, and conspiracy themes.

[3][4] The game is set after a World War III project to create artificial intelligence known as TITANs has gone rogue, resulting in the deaths of over 90% of the inhabitants of Earth.

Earth is subsequently abandoned, and existing colonies throughout the Solar System are expanded to accommodate the refugees.

Nanotechnology, terraforming, Zero-G living, upgrading animal sapience, and reputation systems are all used as plot points and background.

With all of this, the game encourages players to confront existential threats like aliens, weapons of mass destruction, Exsurgent Virus outbreaks, and political unrest.