Econazole

[4] Econazole is used as a cream to treat skin infections such as athlete's foot, tinea, pityriasis versicolor, ringworm, and jock itch.

[citation needed] Econazole nitrate exhibits strong anti-feeding properties against the keratin-digesting common clothes moth Tineola bisselliella.

The most common symptoms were burning, itching, redness (erythema), and one outbreak of a pruritic rash.

[6] Imidazoles devoid of the nitro group no longer have any antiprotozoal activity, however, such drugs are effective antifungal agents.

[citation needed] Alkylation of imidazole (2) with bromoketone (1) prepared from o,p-dichloroacetophenone affords the displacement product (3).

Econazole synthesis: [ 7 ] DE 1940388 U.S. patent 3,717,655 (1970, 1973 both to Janssen ).