The Ecstasy of St Margaret of Cortona is an oil on canvas painting by the Italian Baroque painter Giovanni Lanfranco, executed in 1622.

The baroque arrangement by Lanfranco, places the figures along a diagonal in the canvas and grants a realistic solidity to the characters, focusing the attention on Margaret's psychic state and not only her overpowering miraculous vision.

The painting was commissioned in 1622 by Nicolo Gerolamo Venuti, whose coat of arms is at the lower left, and decorated at the main altar for the church of Santa Maria Nuova in Cortona.

[1] It was purchased for the palace by Prince Ferdinand de' Medici, who provided to the church a replacement canvas on the same subject by Giuseppe Maria Crespi.

In turn, this painting may have influenced the design of the statuary group (1645-1662) depicting the Ecstasy of St Theresa by Gian Lorenzo Bernini.