On August 4, 1852 Venezuela sent a diplomatic delegation in Quito and named José Julián Ponce as finance administrator.

Ecuador officially joined the Bolivarian Alliance for the Americas (ALBA), a Venezuelan regional cooperation initiative, in June 2009.

[1] After President Rafael Correa was replaced by Lenin Moreno in 2017, there was a radical turn in the relations with Venezuela.

[2] [3] In July 2018, President Lenín Moreno of Ecuador distanced himself from ALBA, stating that the organization "has not worked for awhile".

[5] Correa, who was an ally of Venezuela's Bolivarian government and shared his 21st century socialism ideas, was defended by Venezuelan president Nicolás Maduro.