She excavated at several places in Egypt and is mainly known for her work at several sites in the Faiyum, most notably the temple of Medinet Maadi.

[3] In 1974 the University of Pisa appointed Bresciani at the lead of an excavation campaign at Saqqara; here she studied the 26th Dynasty tomb of the vizier Bakenrenef.

In 1978 she founded the still–running Egitto e Vicino Oriente, the Egyptological journal of the University.

She also performed excavations at the "Temple of Million Years" of Thutmose IV at Thebes.

She earned a medal for meritorious science and culture in May 1996,[4] and was a fellow of the Accademia dei Lincei.