He received international attention after the release of his single, "Sitya Loss" in 2014 and an accompanying viral video that featured the Ghetto Kids.

[9] Initially, Kenzo aspired to be a professional footballer[11] and joined Masaka Local Council FC's camp at the age of 9.

A YouTube video featuring a group of Ugandan children known as the Ghetto Kids dancing to the song went viral after it was shared on social media by record executive Sean Combs in September 2014.

[16][22][23] After the release of "Sitya Loss" and the album of the same name, Kenzo went on a brief United States tour with dancehall musician, DeMarco.

[24] In January 2015, Kenzo performed at the opening ceremonies of that year's Africa Cup of Nations in Equatorial Guinea alongside Akon.

[40] In May 2017, Kenzo was named the ambassador of the Kenyan Tourism Board[41] and was appointed to a similar role in Uganda the following year.

"[46] In July 2018, he performed alongside Triplets Ghetto Kids at multiple African music festivals in Canada, including Afrofest in Toronto.

[51] In March 2019, it was announced that Kenzo would be featured alongside Triplets Ghetto Kids in an upcoming music video for American singer Chris Brown's "Back to Love".

[19] Kenzo followed up with the 2021 studio album "Made in Africa" featuring Hunter Nation[53] from Tanzania for the hit love song "SoulMate".

[57]On 22nd August 2024, Eddy Kenzo was appointed as the Senior Presidential Adviser on Creatives by President Yoweri Museveni.

Kenzo’s appointment is seen as a significant step towards bolstering the creative industry in Uganda, which has been seeking more governmental support and recognition.

[63] In January 2016, he enlisted Ugandan footballers, Tony Mawejje and Vincent Kayizzi, to help donate goods to nursing mothers and staff at the local Masaka hospital.

The event aimed to foster unity between two of Uganda's prominent musicians and political figures, Bobi Wine and Bebe Cool, who have had a longstanding feud.

[71] On 26 December 2014, Rema Namakula and Eddy Kenzo had a daughter at Paragon Hospital, in the Kampala neighborhood of Bugoloobi.

[73][74][75] In early 2024, Kenzo appeared in photographs with Phiona Nyamutoro during her inauguration ceremony, after being appointed a State Minister of Energy by President Museveni.

On 30th June 2024, Kenzo made the union with Phiona Nyamutoro official with a traditional introduction ceremony that was held in Buziga, a suburb in Kampala.