The Edenton District Brigade was an administrative division of the North Carolina militia during the American Revolutionary War (1776–1783).

This unit was established by the North Carolina Provincial Congress on May 4, 1776, and disbanded at the end of the war.

John Pugh was commissioned as a Brigadier General commanding the Edenton District Brigade on May 12, 1779; however, he resigned his position after three days to take up a new position as a colonel on the staff of Major General Caswell, commander of the North Carolina Militia and State Troops.

Thomas Benbury served as commander for a short time in October 1780 when general Gregory was in the western part of the state.

They were marched to join up with the recently arrived Major General Horatio Gates of the Continental Army, and led into South Carolina to stop the British if possible.

The colonels included:[15] The Hertford County Regiment was known to have been engaged in three battles: Battle of Great Bridge in Virginia on December 9, 1775, Siege of Charleston in South Carolina from March 28 to May 12, 1780, and the skirmish in Hillsborough in North Carolina on September 12, 1781.

The regiment was transferred to the Halifax District Brigade of the North Carolina militia under Brigadier General Allen Jones in December 1777.

[27] On 15 August 2001, there was a re-dedication of a Grave Marker for the Revolutionary War General Isaac Gregory, which, in part, reads: "from January through July, General Gregory with his Militia, having returned to the Northwest River Bridge [the location of Black Swamp on the border of North Carolina and Virginia] again successfully guarded & defended the Edenton Military District (the counties bordering the Albemarle Sound or Chowan River), this time through repeated engagements around the Dismal Swamp [i.e. Black Swamp] against the army from Norfolk [Kemps Landing] … until the British retreated from Portsmouth to Yorktown in August of 1781.

"[28] "General Gregory's existing tombstone, erected before 1920 by the D.A.R., marked his grave in the field between Fairfield Hall and the Palmer Road about 200 yards south of the home; but it fell in the 1970's, was stolen and then shortly recovered by the sheriff, and finally was garaged for three decades by a family member.

The stone has been erected again now in front of the Sawyer Cemetery, directly across the Palmer Road from the site of Fairfield Hall and the grave, by Edenton's S.A.R.