[5][8] Bove started playing football in the Roman club of Boreale Donorione until 2012, when he joined Roma after following a successful trial under the supervision of Bruno Conti.

[10] Bove made his professional debut for Roma on the 9 May 2021, replacing Ebrima Darboe in the second half of a 5–0 Serie A win against Crotone at the Stadio Olimpico.

[19] The following morning, journalist Matteo Dovellini for the newspaper la Repubblica reported that Bove had been "extubated", was "lucid", and had no cerebral or cardiac damage.

[5][8] During his second season at Roma, José Mourinho labeled Bove a "sick dog", due to his intensity and aggressiveness on the pitch, a nickname that quickly became popular among fans.

[21][22] Off the pitch, Bove enrolled in an economics and management course at Luiss University in Rome, studying part-time, after achieving the highest possible score on his school-leaving tests.