He then joined rivals Barcelona, with whom he played for six years between 1914 and 1920, helping the club win three Catalan Championships and one Copa del Rey in 1920.

Unlike most teams, whose sources of power is either the attack or the midfield, FC Espanya's biggest strength was this back-line, which was the fundamental piece behind the team's rise in Catalonia, competing head-to-head against the likes of Barcelona and Espanyol, and winning two back-to-back Catalan championships in 1912–13 and 1913–14, thus qualifying to the Copa del Rey in which he helped the club reach the 1914 Copa del Rey Final, which still stands as the only cup final of the club's history, but Reguera missed it due to injury and without him, FC Espanya were beaten 1–2 by Athletic Bilbao.

[2] At the end of the twenties, he promoted the Barça football school, trained the lower categories of the club, and served as second coach of the first team.

[3] Like many other FC Barcelona players of that time, Reguera played a few matches for the Catalan national team in 1915, netting one goal in a 2–2 draw with Basque Country on 7 February 1915.

Reguera was a member of the side that participated in the first edition of the Prince of Asturias Cup, an inter-regional competition organized by the RFEF.