Edward, Prince Palatine of the Rhine (Eduard, Prinz von der Pfalz) (5 October 1625 – 10 March 1663), was the sixth son of Frederick V, Elector Palatine (of the House of Wittelsbach), the "Winter King" of Bohemia, by his consort, the British princess Elizabeth Stuart.

Edward was born in The Hague, where his parents lived in exile after his father lost the Battle of White Mountain and was driven from the thrones of both Bohemia and the Palatinate.

On 24 April 1645, in Paris, Edward married a French princess of Italian extraction, Anne Gonzaga (1616–1684).

Nine years older than Edward, she was a daughter of Carlo I, Duke of Mantua and Catherine de Lorraine-Guise-Mayenne.

She had been raised in France, where her father held the dukedom of Nevers prior to inheriting the Italian duchy.