Elisabeth of Hesse (13 February 1539 – 14 March 1582) was a German noblewoman, by birth a member of the House of Hesse and by virtue of marriage Electress of Pfalz-Simmern.

[1] She was born as the seventh child and fourth daughter of Philip I, Landgrave of Hesse and his wife, Duchess Christine of Saxony, daughter of George, Duke of Saxony.

On 8 July 1560 she married Louis VI, Elector Palatine.

They had twelve children in just fifteen years, but only four of them survived childhood: She died (from an illness associated with painless discharge of pus and blood from the intestines, as is evident from Marius' letters and councils to Elisabeth's husband, Elector Ludwig VI[4]) a year before her husband and was buried on April 1, 1582, in the Church of the Holy Spirit (Heidelberg).

This article about a member of the German nobility is a stub.