In December 1853, he joined his brother Samuel Southerden in a drapery partnership in Brisbane Street, Ipswich.
[2] In 1879, Southerden advocated for Sandgate, a beachside area north of Brisbane, to be proclaimed a town.
[12] Southerden was active in lobbying the Queensland Government for the construction of the Sandgate railway line from Brisbane, which was completed in 1882.
[2][14] Southerden was an active member of the Wharf Street Congregational Church in Brisbane for many years.
[2] In 1882, he sold the house at Wickham Terrace to Richard Edwards, another Queen Street merchant, who renamed it Bryntirion.