Bryntirion is a heritage-listed detached house at 287 Wickham Terrace, Spring Hill, City of Brisbane, Queensland, Australia.

[1] The house was built in 1861 for Edward Barton Southerden, a successful Queen Street draper and later first Mayor of Sandgate, to a design by James Furnival who had recently established his practice in Brisbane.

[1] Bryntirion is a chamferboard house on a stone foundation with a corrugated iron roof, built in 1861 with subsequent additions to the rear, front and western elevations.

This wing is further extended by a single storey gable roofed timber structure originally built as a stables and servants accommodation.

A narrow gable roofed timber addition, built in the 1930s, extends along the western side of the stone based rear wing.

It now features a projecting gable roofed room on the eastern side, a classically detailed entry porch in the centre and an attached rotunda with an ogee profiled cupola on the south west corner.

Bryntirion is important in demonstrating the principal characteristics of the layout and planting of a large private garden dating from the late nineteenth century; and of a residence built in the 1860s and extended over time.

Bryntirion is important in exhibiting a range of aesthetic characteristics valued by Brisbane's community, in particular the picturesque composition of the building's architectural elements and the contribution of the established garden to the Wickham Terrace and Burley Street streetscape.