In 1826, he became the pastor of Park Street Church in Boston, Massachusetts.

[1] Beecher hoped to inspire more Biblical purity among parishioners and, as a result, disciplinary actions at the Park Street Church were at an all-time high under Beecher's tenure.

[2] He married Isabella (Porter) Jones in 1829 and together they had eleven children.

He was a close friend of Elijah P. Lovejoy and helped organize the first anti-slavery society in Illinois.

His wife, Isabella, wrote to his sister, Harriet Beecher Stowe, to inspire her to write Uncle Tom's Cabin.