Edward Holme FLS (17 February 1770 – 28 November 1847) was an English physician and supporter of learned societies.

[1] Early in 1794 Holme began practice in Manchester, and was shortly afterwards elected one of the physicians to the infirmary there.

He joined the Manchester Literary and Philosophical Society, and was one of its Vice-Presidents from 1797 to 1844, when he succeeded John Dalton as President.

He was for many years, particularly after the death of John Ferriar, a leader in the medical profession in Manchester, and in the local literary and scientific societies.

[1] Holme's Leyden dissertation De Structura et Usu Vasorum Absorbentium ran to 61 pages.