Edward Stafford, 2nd Earl of Wiltshire KB (7 April 1470 – 24 March 1499) was an English nobleman.

He was made a Knight of the Bath on 18 April 1475, and on 16 March and 1 June of that year Sir Ralph Hastings was appointed steward of his lands during his minority, while his 'governance and tuition' were entrusted to his grandmother, Anne, Duchess of Buckingham.

On 25 November 1487 he attended the coronation of King Henry VII's Queen, Elizabeth of York.

He was with the forces which fought against the Cornish rebels at Blackheath on 17 June 1497, and on 11 September 1498 entertained the King at Drayton.

[3] Stafford left a will dated 21 March 1499, summarized by Harris in Testamenta Vetusta, requesting burial in St. Peter's Church, Lowick:[4] My body to be buried in the Church of St. Peter of Lufwyke, in the County of Northampton, in Our Lady's aisle, by my grandfather Greene; and I will that my executors make a convenient tomb there for me.By settlement dated 13 July 1494 Stafford married Margaret Grey, the daughter of Edward Grey, Viscount Lisle, by Elizabeth Talbot, suo jure Baroness Lisle of Kingston Lisle.