Following his brother Thomas's rebellion, Edward was questioned by the Privy Council on 3 May 1557, but no connection was found.
Edward followed his uncle Henry Stafford as Member of Parliament for Stafford in 1558 and 1559[1] and after his ennoblement was summoned to the House of Lords (1573–1593)[2] Caus Castle was part of the marriage settlement between the arranged marriage of John Thynne and Joan Hayward.
However, Stafford disputed the ownership of the castle and he had to be ejected by force in 1591.
[3] From about 1574, Stafford was patron of a "Lord Stafford's Company of Players", who were first recorded appearing in Barnstaple, appearing often in public records for the next twenty-six years.
He became the 3rd Baron Stafford on his elder brother Henry's death in 1566.