Edwin Thompson Denig (March 10, 1812 – September 4, 1858) was an American fur trader and pioneer ethnographer active at Fort Union, in present-day North Dakota.

Denig was the son of a prosperous county doctor, yet he chose to dedicate his adult life to the fur trade.

There he rose from bookkeeper to chief clerk, and finally Bourgeois (superintendent of the post and profit-sharing partner).

His first marriage was to Sina Wamniomi (Whirlwind Blanket), a Lakota, with whom he had a son, Robert, and a daughter, Sarah.

His second marriage, in 1837, was with Hai-kees-kak-wee-yah (Deer Little Woman), an Assiniboine, with whom he had one son, Alexander, and two daughters, Ida and Adeline.