Other painters from the same region around the same period included Andreas Karantinos and Gerasimos Pitsamanos.
He painted icons and frescos for Santi Pietro e Paolo dei Greci.
In 1767, he painted some works in an Orthodox Church in the village of Villa Badessa in the region of Abruzzo.
His second book Sen Timenti di un Concittadino Delle Isole Ionie ai Suoi Con Cittadini (Feelings of a citizen of the Ionian Islands to his fellow citizens) was published in Milan around 1802.
[9][10] Spyridon Sperantzas was associated with the Greek Orthodox Church of San Nicolò dei Greci in Trieste 1784-1795.
San Nicolò dei Greci was forced to hire an Italian painter named Giacomo Granziosi.
[11][12] Karousos's work was so unique eventually his style broke away from contemporary Heptanese art of the Ionian Islands.
Belisario Corenzio completed some work for the church Santi Pietro e Paolo dei Greci and Karousos was exposed to it.
Some of his signature poems were Ποίημα του ταπεινού καί ευσεβούς δούλου τοΰ Θεού Ευσταθίου τού Καρούσου τού έκ Κεφαλληνίας ορμώμενου (Poem of the humble and pious servant of God Efstathios of Karousos from Cephalonia) and Ευστάθιος Καροΰσος Κεφαλληνιεύς έν Νεαπόλει έποίησε (Efstathios Karousos of Cephalonia and Naples).