Notable astronomers that have worked or directed the observatory include Willem de Sitter, Ejnar Hertzsprung and Jan Oort.

For the next two years, Lotharius Zumbach de Coesfeld ran the observatory until his appointment as professor of mathematics in Kassel in 1708.

[2] Gravesande's successor was Johan Lulofs who used the observatory to observe Halley's comet in 1759 and solar transits of Mercury (in 1743 and 1753) and Venus (in 1761).

For a number of years the curators attempted to find a suitable astronomer to look after the observatory, eventually employing Jan Frederik van Beeck Calkoen in 1799, who left in 1805.

Kaiser also acquired a number of new instruments and telescopes with which he made observations including that of comets, planets, and binary stars.

[2] As a result of the increased interest in astronomy brought about due to Kaiser's popular writings and teachings, a commission was founded in 1853 to fund a new observatory.

Einstein was a frequent visitor of the building during his professorship at Leiden university due to his good friendship with the director, Willem de Sitter.

On 21 October 2015, Einstein's Chair got a short segment on the Dutch astronomy program Heel Nederland Kijkt Sterren.

While not longer the base for the modern Leiden Observatory academically, it does have the astronomical historical items at the facility.

Also, a solar telescope was crowd funded to provide live optically transmitted images of the Sun to the Visitor center, which is also known to have offered tours.