Eisack Valley (Italian: Valle Isarco [ˈvalle iˈzarko]; German: Eisacktal) is a district (Italian: comprensorio; German: Bezirksgemeinschaft) in South Tyrol, Italy.

It comprises the middle part of the valley of the Eisack, from Franzensfeste in the north to Waidbruck in the south.

The valley of the Eisack river stretches from Brenner Pass southwards down to its confluence with the Adige near Bolzano.

The upper valley north of Franzensfeste is known as Wipptal, while the lower parts belong to the Salten-Schlern administrative district.

According to the 2001 census, 85.76% of the population of the valley speak German, 13.22% Italian and 1.02% Ladin as first language.