Mekwunye started his career being a camera assistant at his church before getting a job at Africa Magic producing 53extra and Jara as well as all Channel O contents in Nigeria.

[10] He directed his first feature film, which he also produced with Chidinma Uzodike titled Light In The Dark, which was released in Nigerian and Ghanaian cinemas[11] on 25 January 2019.

He directed his second feature film, which he also produced titled 'One Lagos Night'[17] that was acquired exclusively by Netflix[18] and the international release on their platform was on 29 May 2021.

[20] In 2022, he made a film titled 'Honey Money' starring Nancy Isime, Timini Egbuson, Iyabo Ojo, Femi Branch, Babarex, Uzee Usman, Sandra Okunzuwa, Junior Pope etc.

[25] He is also an adjunct faculty[26] at the School of Media and Communication, Pan Atlantic University where he teaches final year students film production and techniques.

He was one of the speakers invited by Massachusetts Institute of Technology (MIT) to speak at a conference titled 'Videography In the Hands of the People' which held at the school campus in October 2022 in Boston.